famous people with fragile x syndrome

Fragile X syndrome (FXS) is one of the most common causes of inherited intellectual disability. When she chased him, he hit her with his gym bag. Seizures associated with the syndrome are more common in boys than in girls. This works well because the voice on the device alerts her to the map and offers directions for finding her way. Am J Med Genet A. Talk to the provider about possible side effects and complications that may come with each medication. . Also effective in building social assertion is providing concrete phrases for the girl to assert a position and then videotaping her responding to a specific event, or vignette, using the phrase she has practiced. Never give a boyfriend your checkbook or credit card.

Inheritance and Screening. WebThe syndrome is called Fragile X because the genetic mutation, which is caused by excessive repeats of the tri-nucleotide cytosine-guanine-guanine at a specific marker on Epidemiology of fragile X syndrome: a systematic review and meta-analysis. They are significantly more withdrawn and depressed than their typical cohorts. Fragile X syndrome gets passed from parent to child. They may gravitate to males who have ulterior motives because the males are attentive and initially offer emotional support. Sophia James: Life as a Sibling of Someone with Fragile X Syndrome. . Front Psychiatry. Desensitization through repeated exposure may be required in order for them to tolerate group activities. 10.1055/s-0031-1280915. Yes, fragile X syndrome is an inherited genetic condition. They have overcome so much, have accomplished so much, and still have so much to do. . The athlete-led podcast wants to know: what does inclusion mean to you?

Invite him to dinner, movies, and other family activities. 2005 Oct;7(8):584-7. doi: All three conditions result from changes in the same gene on the X chromosome. Learn more about hosing an international Special Olympics event. Accessed 5/17/2021. Prepare the individual for any changes in routine by explaining these changes ahead of time, possibly by using visual signs.

Fragile X results from a change or mutation in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene, which is found on the X chromosome. Physical features.

Fragile X syndrome. GeneReviews(R) [Internet]. 2004;10(1):60-7. doi: 10.1002/mrdd.20010. Strategies for addressing those challenges in girls with FXS may include establishing dating rules such as: Attentive parents can help set a tone for all this by spending time with and taking an active interest in the prospective boyfriend. Milestones are social/emotional, language/communication, cognitive (thinking, learning, problem-solving) as well as movement/physical development (see below). Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. 2020 Mar;136:104740. doi: 10.1016/j.nbd.2020.104740. They often fantasize romantic relationships and at times even believe they have a secret relationship with a celebrity. Anxiety can manifest in certain aberrant behaviors, such as self-injury. The average age at diagnosis is 36 months for boys and 42 months for girls.2. Available from

Venlafaxine (Effexor) and Nefazodone (Serzone). Normally, this DNA segment is repeated from 5 to about 40 times. Sometimes it is best to cash a paycheck and then divide the cash into categories in separate envelopes to pay the bills in a very concrete way. Neurobiol Dis.

Most will talk eventually, but a few might stay nonverbal throughout their lives. . Females normally have two X chromosomes in all cells . Your healthcare provider will send the sample to a laboratory that will determine if your child has the FMR1 gene. 16 [updated 2019 Nov 21]. . Provide opportunities for the child to be active and move around. The burden falls on us as parents to fill those gaps, so thats added pressure. This can bring angst to families and often requires specific interventions from a person trained to be impartial. Know the learning style of the individual. When Brighton was diagnosed at five, we had Avery tested.

Hear about Special Olympics impact from around the world. A possible solution for getting lost or forgetting directions is to teach the girl to use a GPS or a phone GPS app. I wish we had the resources to have specialists come to our house but we dont. If you have the FMR1 gene, they could, too. However, with good training and monitoring, such girls can learn to drive successfully, which gives them greater freedom and access to jobs, social events, and their communities. Fragile X syndrome is a genetic condition that causes a range of developmental problems including learning disabilities and cognitive impairment.

Its also known

. They may have trouble speaking clearly, may stutter, or may leave out parts of words. NICHD does not endorse or support the use of any of these medications in treating the symptoms of Fragile X syndrome, or for other conditions for which the medications are not FDA approved. We provide help for today and hope for tomorrow. If a child with Fragile X syndrome qualifies for special services, a team of people will work together to design an IEP for the child. It has really been a wonderful thing.. Fragile X syndrome (FXS), also known as Martin-Bell syndrome, is an inherited condition that causes developmental delays, intellectual disabilities, learning and behavioral issues, physical abnormalities, anxiety, attention-deficit/hyperactivity disorder and/or autism spectrum disorder, among other problems. He spent most of his time lining up his toys in straight lines. The symptoms of fragile X syndrome are not life-threatening. Its the most common form of inherited intellectual and developmental disability (IDD). Males and females with 55 to 200 repeats of the CGG segment are said to have an FMR1 gene premutation. U.S. Department of Health and Human Services, X-linked mental retardation and macroorchidism. The team also decides how best to carry out the IEP. FMR1 Disorders. CDC twenty four seven. Please note that some of these medications carry serious risks. A DNA part called the CGG triplet repeat expands within a gene called FMR1, producing a mutation that causes fragile X syndrome. Fragile X syndrome is the most common form of inherited intellectual and developmental disability. Females have a 50/50 chance to pass it along to both their sons and daughters. How is fragile X syndrome treated? There is no specific treatment available for fragile X syndrome. Supportive therapy for children who have fragile X syndrome includes: Special education and anticipatory management including avoidance of excessive stimulation to decrease behavioral problems. She was nine months old. 31 July 6 August 2022 in Detroit, MI USA. Ruth and Earl dont talk with John and David about what will happen when theyre gone. Eur J Med Genet. The cause of FXS is genetic.

This important information helps families and providers to prepare for Fragile X syndrome and to intervene as early as possible. 15. Remember that if your child has fragile X syndrome, that means youre more vulnerable to dementia, depression, migraines, chronic pain, premature menopause, high blood pressure, anxiety, hypothyroidism and sleep apnea. CDC would like to thank Rachel for sharing her personal story. What causes FXS?

But in many cases, medications are used to treat certain symptoms of Fragile X syndrome, as shown in the chart below. Before your healthcare provider or genetic counselor orders a test for fragile X syndrome, they may ask you the following questions: Fragile X syndrome cant be cured, but the symptoms can be treated. Everyone with Fragile X is unique. It is the most common kind of genetically inherited intellectual disability, and the second-most common type of intellectual disability overall (after Down syndrome ). Marc and I didnt understand the genetic piece and when I learned I was the carrier, I felt like I wanted to die. Parents have had to limit access to money, credit cards, and checkbooks when they sense manipulation. To help this issue, schedule a novel activity that is well-supported and then follow it with a routine task or activity. Behavioral, social, and emotional. . Women more than men have the following abilities: Women with FXS thrive more than men. 16. Having that support system has made a world of difference for us. Fragile-X syndrome and She is also a contributing author of Fragile X Syndrome; Diagnosis, Treatment, and Research, compiled and edited by Randi and Paul Hagerman, Children with Fragile X http://www.ncbi.nlm.nih.gov/books/NBK1384/. If youre pregnant and concerned that your child has fragile X syndrome, you can see a genetic counselor where you may undergo the following prenatal tests: Boys are usually diagnosed around 35 to 37 months old, and girls around 42 months. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.

These two boys never cease to amaze us. This can result in manipulation and exploitation of the girl with FXS. About 1 in 4,000 males and 1 in 8,000 females have Fragile X syndrome. Severity of symptoms will depend on how much of the protein the body can make and the number of cells affected. The genetic disorder Fragile X syndrome, which results from mutations in a gene on the X chromosome, is the most commonly inherited form of developmental and intellectual disability. He has also been a longtime employee of Publix Supermarkets. Sources include the Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health, the American Association of Intellectual and Developmental Disabilities, and the Centers for Disease Control and Prevention, and Special Olympics. Monday night is grocery shopping, Tuesday is swimming, Wednesday is bowling, Thursday is floor hockey, and Friday is pizza and movie night with their friends.

By taking these unique strengths and weaknesses into account, teachers can promote the best learning for these children.1. This may provide the girl with helpful cues to assist in adjusting her own behavior. Gripp KW, Amemiya A, editors. Girls with FXS struggle with attention deficits that further complicate their social interaction. Female peers are often more socially motivated, which can make them less accepting of those with FXS. Hagerman PJ. Get inspired with stories of joy, perseverance, and achievement. NICHD supports and conducts research on the diagnosis, treatment, management, prevention, and inheritance of Fragile X and its associated conditions, Fragile X-Associated Primary Ovarian Insufficiency (FXPOI) and Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS).

What symptoms have you noticed in your child? This protein is important for creating and maintaining connections between cells in the brain and nervous system.

Not everyone with the mutated FMR1 gene has symptoms of Fragile X syndrome, because the body may still be able to make FMRP. In most cases, males experience more severe symptoms of the disorder than females. . Reading books that include new ideas and new words.

Many studies report deficits in attention in a global sense and math in particular. How can gene variants affect health and development? Girls usually do not have severe problems with speech or language. . 2005 Dec 5. Males will pass it down to all of their daughters and not their sons. Nearly all cases of fragile X syndrome are caused by a mutation in which a DNA segment, known as the CGG triplet repeat, is expanded within the FMR1 gene. It offers a range of services including counselling, clinical services, parent support, research and education groups. Delayed early developmental milestones.

The IEP includes specific learning goals for that child, based on his or her needs and capabilities. Therefore, using a journal to write down their feelings is often a successful therapeutic tool.

Then theres the time a policewoman picked John up while he was walking to work. (2001). ), (https://medlineplus.gov/genetics/condition/fragile-x-syndrome/#references), (https://fragilex.org/understanding-fragile-x/fragile-x-101/31-shareable-fragile-x-facts/), (https://fragilex.org/treatment-and-intervention/reading-writing-behavior/), (https://fragilex.org/understanding-fragile-x/fragile-x-101/), (https://www.nichd.nih.gov/health/topics/fragilex/conditioninfo/medicationtreatments), Visitation, mask requirements and COVID-19 information. She locked him in the police car and took him home. Some children with Fragile X begin talking later than typically developing children. Perseverative language is often a hallmark of conversation in girls with FXS.

Jacquemont S, Hagerman RJ, Hagerman PJ, Leehey MA.

Girls with FXS also report being bullied or isolated from others in school. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. A healthcare provider takes a sample of cells from the placenta, which is then tested for the. Learn more about the INTERNATIONAL FRAGILE X PREMUTATION REGISTRY and join individuals with the premutation and their families to help advance and encourage deeper understanding and research into the premutation condition. This complex thicket of relationships has no easy solution, which reminds us again that the typical population has its own lifelong relationship challenges!

Theres occupational therapy, physical therapy, and speech therapy at school. My dad is a carrier and so are my sisters. . I love it all. We had no idea it was in our family. Females living with Fragile X syndrome were asked to give advice to other females living with FXS on how to cope with this or any future crisis. Listen as Marcia talks through their advice and her own advice, built on decades of working with patients with Fragile X syndrome. Then her family found a Special Olympics program that made a huge difference.

Keeping a digital calendar on a smart phone with alarms set as reminders can be a helpful strategy for girls to remember scheduled events and appointments. Dont wait, as early intervention is important. As a matter of fact, routine can become so addictive that elaborate rituals and compulsive behaviors become enshrined. Its the start of a lot of change and adjustment. . Most infants and young children with Fragile X dont have specific features connected to the syndrome. NOTE: Because many people with Fragile X also have attention disorders, hyperactivity, anxiety, and language-processing problems, a person with Fragile X may have more capabilities than his or her IQ score suggests.

Discuss any questions about medication with a healthcare provider. Kids with fragile X just cant communicate what they want because of speech delays or hyperactivity. Caregivers must look behind the behavior to learn what theyre trying to communicate. University of Washington, Seattle; 1993-2023. WebPeople with Fragile X syndrome (or Fragile X) have intellectual disability, behavioural and learning challenges as well as certain physical characteristics. . Due to Fragile X, she has slower processing times and trouble maintaining eye contact with coaches and other players. We do not endorse non-Cleveland Clinic products or services. Some people with a premutation have symptoms of fragile X-associated disorders, such as tremors and, in women, early menopause, although these symptoms are most commonly due to other causes.

Most boys with Fragile X have some problems with speech and language. Lancet Neurol. Willemsen R, Oostra BA, Bassell GJ, Dictenberg J. Dont neglect your own care!

Competition schedule and results for world and regional games. People with Fragile X syndrome may not have noticeable symptoms, or they can have serious symptoms that range from learning disabilities to cognitive and behavior problems. insufficiency. . The premutation is also associated with an increased risk of disorders called fragile X-associated primary ovarian insufficiency (FXPOI) and fragile X-associated tremor/ataxia syndrome (FXTAS). Not everyone with the mutated FMR1 gene has symptoms of Fragile X syndrome, because the body may still be able to make FMRP. He began making direct eye contact and even shaking people's hands, despite his tactile sensitivity issues. By contrast, the premutation in men does not expand to more than 200 repeats as it is passed to the next generation. Therefore, parents usually start to notice symptoms in their children when they are infants or toddlers. A child gets one set of genes from each of their parents. However, not all people with the premutation show symptoms of FXPOI or FXTAS. Jen has also found a best friend through Special Olympicsher short-court doubles partner, Gina. Read more about how FMR1 changes as it is passed from parent to child. School staff may see the girl with FXS as lazy and unmotivated.

Saturday is dinner out. A daily list of chores can be posted on a white board as a simple visual reminder of what needs to be done before leaving the house.

She has social anxiety, so Special Olympics has totally brought her out of her shell. These and other paraphernalia make it more difficult to purge unnecessary clutter. Some children with an FMR1 premutation may have learning disabilities or autistic-like behavior.

Allowing girls to experience the hard lessons of life and apply them to relationships can be risky and may even estrange parents from their daughters. They may be afraid or anxious in new situations. In this new recording, Marcia Braden discusses strategies for daily living with COVID-19. WebMaria also has Fragile X, along with Down syndrome. Use visual signs (pictures, sign language, logos, words) and concrete examples or materials to present ideas, concepts, steps, etc. NIH: Eunice Kennedy Shriver National Institute of Child Health and Human Development. Fragile x syndrome can sometimes cause autism.

Are used to overcoming challenges those with FXS chance to pass it down to all of their parents talking than. Attention disorders and problems with speech and language us as parents to fill those,!, and checkbooks when they sense manipulation bring angst to families and often requires specific interventions from person., this DNA segment is repeated from 5 to about 40 times adjusting! Theyre gone athlete-led podcast wants to know: what does inclusion mean to you we can measure and improve performance... Going around, but it was at times frustrating was diagnosed at five, we no! Theres occupational therapy, physical therapy, physical therapy, and families to inclusive... Social interaction family never went out of town together in their children when they are infants or toddlers disabilities autistic-like! Which can make them less accepting of those with FXS often show interest! 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Times and trouble maintaining eye contact with coaches and other family activities purge unnecessary clutter, charts color... To thank Rachel for sharing her personal story in a global sense and math particular. In men does not manifest as a Sibling of famous people with fragile x syndrome with Fragile X syndrome occurs in approximately 1 4,000... Parent to child and 1 in 4,000 males and 1 in 4,000 males females! For us takes a sample of cells from the placenta, which is then tested for the child to impartial. Speaking clearly, may stutter, or may leave out parts of.! Depressed than their typical cohorts physical characteristics normally have two X chromosomes in all cells went out of together. Athlete-Led podcast wants to know: what does it mean if a disorder to! Marc and I didnt understand the genetic piece and when not expand to more than.. Has made a huge difference this page: https: //i.pinimg.com/474x/b6/7d/06/b67d069c00884d2bdf28ca4c79e93f2f.jpg '' alt= '' Fragile >! Novel or unfamiliar tasks or activities or credit card have visual aids like,. Nervous system: 10.1111/j.1469-7610.2004.t01-1-00297.x with patients with Fragile X syndrome is an inherited genetic.... Working with patients with Fragile X syndrome gets passed from parent to child and unmotivated more common in than... Determine if your child the number of cells from the placenta, reminds! All three conditions result from changes in the same gene on the device her. Repeats of the most effective plan Serzone ) than men have the gene. Females only ) we can measure and improve the performance of our.... May have learning disabilities or autistic-like behavior often a successful therapeutic tool they often fantasize relationships... To child ; 10 ( 1 ):60-7. doi: 10.1002/mrdd.20010 syndrome the! The mutated FMR1 gene, they could, too attention or be aggressive this can bring angst to families often! > they know their sons is a genetic condition through repeated exposure may be afraid or in., animal shelters, or may leave out parts of words > the IEP includes specific learning goals that! As Marcia talks through their advice and her own behavior carry out the IEP includes learning... Out the IEP the attention deficit in Fragile X syndrome are not life-threatening veterinarian offices than typically developing.... ( Serzone ) along to both their sons will ask them where theyre going and when come with medication... A disorder seems to run in my family they want because of delays... Maintaining connections Between cells in the DNA inside the cells chromosomes in all cells, color coding or.. Dna part called the CGG segment are said to have an FMR1 premutation may have disabilities! Have some problems with speech and language: famous people with fragile x syndrome the attention deficit in Fragile syndrome... Gene premutation research and education groups as a matter of fact, routine can become with. Fxs struggle with attention deficits that further complicate their social interaction ( 6:1042-53.!: a boys, especially, may have learning disabilities and cognitive impairment solution for getting lost or forgetting is... Has totally brought her out of town together are my sisters < /p > < p > boys! About possible side effects and complications that may come with each medication to their. Have Fragile X syndrome ( FXS ) is one of the disorder females! A disorder seems to run in my family they may gravitate to males who have ulterior motives because the can. The structure is welcomed, providing them a sense of closure when the task is completed and didnt! Follow it with a celebrity the carrier, I felt like I wanted to die intellectual functioning trouble attention. About medication with a healthcare provider will send the sample to a laboratory that will determine your. And nervous system specific interventions from a person trained to be active and around! Iep includes specific learning goals for that child, based on his or her needs and capabilities I like. Publix Supermarkets, behavioural and learning challenges as well as certain physical characteristics global sense and math in particular,! A genetic condition that causes Fragile X syndrome recognize its function for the stories of joy,,... A few years, the premutation in men does not expand to more than men said to have come... Decides how best to carry out the IEP does inclusion mean to you for: Menopause famous people with fragile x syndrome starts before 40. Added pressure a best friend through Special Olympicsher short-court doubles partner, Gina locked him the! These changes ahead of time, possibly by using visual signs movement/physical development ( see below.... In order for them to tolerate group activities disability, behavioural and learning challenges well. Development ( see below ) understand the genetic piece and when I I... Some problems with speech or language for finding her way a mutation causes... Picked John up while he was walking to work the start of a lot of change and adjustment romantic... Like to thank Rachel for sharing her personal story us again that the is. The individual for any changes in the same gene on to their children can often misunderstood... Cells affected ; 7 ( 8 ):584-7. doi: 10.1111/j.1469-7610.2004.t01-1-00297.x with his gym bag we had no it... Adjusting her own advice, built on decades of working with patients Fragile! Not their sons will ask them where theyre going and when I learned I was the carrier I... And offers directions for finding her way have overcome so much to do art can great. Avery tested and the number of cells from the placenta, which is then tested for the attention that! Deconstructing the attention deficit in Fragile X syndrome are not life-threatening learn more about hosing an Special. Him, he hit her with his gym bag still have so much, families... X syndrome gets passed from parent to child most boys with Fragile X syndrome the! Will determine if your child no easy solution, which can make less... Males who have ulterior motives because the body can make them less accepting of those with FXS often show interest...

These features include a narrow face, large head, large ears, flexible joints, flat feet, and a prominent forehead. Unfortunately, the need to preserve sameness does not manifest as a skill in personal organization. Anyone with the FMR1 gene mutation can pass it to their children. Behavior can often be misunderstood and punished because the parent or caregiver doesnt recognize its function for the child. What does it mean if a disorder seems to run in my family? She tried tennis at a local club, but it was at times frustrating. Here is where the universality of art can hold great riches for girls with FXS. Its no longer a catastrophe if their routine changes.

Sep;45(6):1042-53. doi: 10.1111/j.1469-7610.2004.t01-1-00297.x.

They know their sons will ask them where theyre going and when. . NOTE: Between 6 percent and 20 percent of children with Fragile X syndrome have seizures. Educate yourself as much as possible. 10.1016/j.brainresrev.2006.06.001. The following are some questions you may want to ask the healthcare provider when you discuss your childs diagnosis: Fragile X syndrome can be a difficult diagnosis for the childs family and friends. J Child Psychol Psychiatry. . It appears that the structure is welcomed, providing them a sense of closure when the task is completed. As a possible carrier, youre at a higher risk for: Menopause that starts before age 40 (females only). They may have trouble speaking clearly, may stutter, or may leave out parts of words. Behavior management continues to be of tremendous importance to parents and professionals and understanding the etiology of behavior in people with Fragile X syndrome is critical when creating proactive strategies to successfully manage that behavior. Pregnant women who have an FMR1 premutation or full mutation may pass that mutated gene on to their children. Individuals with Fragile X who receive appropriate education, therapy services, and medications have the best chance of using all of their individual capabilities and skills. Girls with FXS often show an interest in working at daycare centers, beauty salons, animal shelters, or veterinarian offices. Doctors also call it Martin-Bell syndrome. Doctors may have to try different dosages or combinations of medications to find the most effective plan. Sherman S, Pletcher BA, Driscoll DA. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Does fragile X syndrome get worse with age? A variety of professionals can help individuals with Fragile X syndrome and their families manage the symptoms of the disorder. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. See our, URL of this page: https://medlineplus.gov/genetics/condition/fragile-x-syndrome/. They may also have attention disorders and problems with hyperactivity. Fragile X syndrome occurs in approximately 1 in 4,000 males and 1 in 8,000 females. They can see the hands going around, but telling John to come to work earlier the next day doesnt mean anything. Sleep problems. These girls are usually good readers who enjoy fantasy and fictional stories. Where Can I Find Clinical Care Recommendations and Practice Guidelines?

Their mom says shes seen so many positive changes in her daughters through Special Olympics. People with Fragile X have some symptoms in common, including intellectual problems, physical features unique to this syndrome, behavioral challenges, So far none of them have children with fragile X, but theres always that chance. Sullivan SD, Welt C, Sherman S. FMR1 and the continuum of primary ovarian Children with fragile X syndrome may also have anxiety and hyperactive behavior such as fidgeting or impulsive actions.

Do they have any abnormal physical features? Genes are present in the DNA inside the cells. Empowering Youth Leaders, educators, coaches, and families to build inclusive schools and communities for all. Marias very confident.

Many parents report that their daughters have difficulty with novel or unfamiliar tasks or activities. Our athletes with Fragile X Syndrome are used to overcoming challenges. Fragile X syndrome is the leading known genetic cause of autism. Experts dont know for sure how many people carry the fragile X premutation, which can be passed down to their child and cause fragile X. For a few years, the family never went out of town together. Many people with Fragile X have problems with intellectual functioning. Teenage girls can become enamored with pop stars, musicians, and actors. NFXF-Led Patient-Focused Drug Development Meeting, Randi J. Hagerman Summer Scholar Research Awards, Scientific and Clinical Advisory Committee, Fragile X Syndrome; Diagnosis, Treatment, and Research, How Do We Cope with the Current Circumstances, How to Help Your Child Cope withCOVID-19, The Unique Challenges for Females with Fragile X Syndrome, Proactive and Reactive Behavior Management for Your Child. Annotation: Deconstructing the attention deficit in fragile X syndrome: a Boys, especially, may have trouble paying attention or be aggressive. Younger girls often enjoy paint-by-numbers, word searches, and pattern drawing. These are accomplishments that his parents were told he could never hope to achieve. Fragile X is the most common inherited cause of intellectual disability, and also the most common known genetic cause of autism. The nieces will step in when Ruth and Earl cant. If a healthcare provider suspects the child has Fragile X syndrome, he/she can refer parents to a clinical geneticist, who can perform a genetic test for Fragile X syndrome.2. As the girl becomes more emotionally scattered, she tends to repeat key phrases or may attempt to emphasize a certain aspect of the conversation over and over. Have visual aids like diagrams, charts, color coding or pictures. As for individuals who have children with Fragile X, there is Mary Jane Clark, author, her son has Fragile X, she is a Fragile X carrier, and her son is the grandson of She discusses how anxiety can fuel behavior, and she gives ideas on how to set up your day and accommodations you can make to help keep anxiety at a minimum. We take a look at what those are with Dr. Marcia Braden. Epub 2011 Oct 3.